Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents.

Abstract:

:A series of the titled compounds was synthesized and tested for anti-Helicobacter pylori activities. We discovered Y-34867 having the most potent activity against Helicobacter pylori among the quinolones tested along with high photostability. Furthermore, Y-34867 showed an excellent therapeutic effect in the experimental Helicobacter pylori infected Mongolian gerbil model.

journal_name

Bioorg Med Chem Lett

authors

Sakurai N,Sano M,Hirayama F,Kuroda T,Uemori S,Moriguchi A,Yamamoto K,Ikeda Y,Kawakita T

doi

10.1016/s0960-894x(98)00390-4

subject

Has Abstract

pub_date

1998-08-18 00:00:00

pages

2185-90

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960894X98003904

journal_volume

8

pub_type

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