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Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group.

Abstract：

:A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbamoyl group at the 5 or 6 position of the benzofuran ring were synthesized and evaluated for rat and human testosterone 5 alpha-reductase inhibitory activities in vitro. They had inhibitory activities against both enzymes and the 6-carbamoyl derivatives tended to be more potent than the 5-carbamoyl compounds.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ishibashi K,Nakajima K,Sugioka Y,Sugiyama M,Hamada T,Horikoshi H,Nishi T

doi

10.1016/s0960-894x(98)00001-8

subject

Has Abstract

pub_date

1998-03-17 00:00:00

pages

561-6

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960894X98000018

journal_volume

8

pub_type

杂志文章

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