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Design, synthesis and anticancer activity of novel hybrid compounds between benzofuran and N-aryl piperazine.

Abstract：

:A series of novel hybrid compounds between benzofuran and N-aryl piperazine have been designed and prepared. These derivatives were evaluated for their in vitro anti-tumor activity against a panel of human tumor cell lines by MTT assay. The results demonstrated that amide derivatives were more bioactive than sulfonamide compounds in general, and that chloro or trifluoromethyl substituent was vital for modulating cytotoxic activity. In particular, compound 13 was found to be the most potent compound against 4 strains human tumor cell lines, and exhibited cytotoxic activity selectively against Hela (0.03μM).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Mao ZW,Zheng X,Lin YP,Hu CY,Wang XL,Wan CP,Rao GX

doi

10.1016/j.bmcl.2016.06.055

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

3421-4

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(16)30666-7

journal_volume

26

pub_type

杂志文章

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