Abstract:
:The B(6) vitamers have been shown to display beneficial therapeutic effects in cardiovascular related disorders. The design of novel antiplatelet agents using pyridoxine as a template has led to the discovery of a class of novel cardio- and cerebro-protective agents. The present study describes the synthesis of several of these derivatives along with the antiplatelet and antiischemic activity of derivative 16.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Zhang W,Yao J,Pham V,Whitney T,Froese D,Friesen A,Stang L,Xu C,Shuaib A,Diakur JM,Haque Wdoi
10.1016/j.bmcl.2004.06.079subject
Has Abstractpub_date
2004-09-20 00:00:00pages
4747-50issue
18eissn
0960-894Xissn
1464-3405pii
S0960-894X(04)00854-6journal_volume
14pub_type
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