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Dodecyl sorbitan ethers as antimicrobials against Gram-positive bacteria.

Abstract：

:A range of amphiphilic sorbitan ethers has been synthesized in two steps from sorbitan following an acetalization/hydrogenolysis sequence. These sorbitan ethers and the acetal intermediates have been evaluated as antimicrobials against Gram-negative and Gram-positive bacteria. No antimicrobial activity was observed for Gram-negative bacteria. However, the compounds bearing a linear dodecyl chain exhibit antimicrobial activity (MIC as low as 8μg/mL) against Gram-positive bacteria such as Listeria monocytogenes, Enterococcus faecalis and Staphylococcus aureus. Encouraged by these preliminary results, dodecyl sorbitan was tested against a range of resistant strains and was found to be active against vancomycin-, methicillin- and daptomycin-resistant strains (MIC=32-64μg/mL).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Belmessieri D,Gozlan C,Duclos MC,Dumitrescu O,Lina G,Redl A,Duguet N,Lemaire M

doi

10.1016/j.bmcl.2017.09.015

subject

Has Abstract

pub_date

2017-10-15 00:00:00

pages

4660-4663

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(17)30900-9

journal_volume

27

pub_type

杂志文章

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