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A novel solid support for synthesis of oligonucleotide 3'-phosphorothioate monoesters.

Abstract：

:A new reagent immobilized on solid support allowing for solid-phase synthesis of oligonucleotides with a 3'-terminal phosphorothioate monoester is described. The support is compatible with phosphoramidite chemistry for automated oligonucleotide synthesis. Final deprotection with ammonia under standard conditions leads to oligonucleotide 3'-terminal phosphorothioate.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Cheruvallath ZS,Cole DL,Ravikumar VT

doi

10.1016/s0960-894x(02)00922-8

subject

Has Abstract

pub_date

2003-01-20 00:00:00

pages

281-4

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960894X02009228

journal_volume

13

pub_type

杂志文章

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