Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of N,N'-bis[2-oxo-2H-benzopyran]-3-carboxamides.

Abstract:

:A novel series of N,N'-bis[2-oxo-2H-1-benzopyran]-3-carboxamide derivatives have been synthesized and investigated for the ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). Some of the synthesized compounds show good selective inhibitory activity against the MAO-A isoform. Both the MAO-A and -B isoforms, deposited in the Protein Data Bank as the 2BXR and 1GOS models, respectively, were considered in a computational study performed with docking techniques on the most active and selective inhibitors.

journal_name

Bioorg Med Chem Lett

authors

Chimenti F,Secci D,Bolasco A,Chimenti P,Granese A,Carradori S,Befani O,Turini P,Alcaro S,Ortuso F

doi

10.1016/j.bmcl.2006.04.026

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

4135-40

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00458-6

journal_volume

16

pub_type

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