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Synthesis of cholestane glycosides bearing OSW-1 disaccharide or its 1-->4-linked analogue and their antitumor activities.

Abstract：

:For further structure-activity relationship (SAR) research of OSW saponins, a cholestane glycoside, namely 3beta, 16beta, 26-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-beta-D-xylopyranosyl)-(1-->3)-2-O-acetyl-alpha-L-arabinopyranoside (1) together with two 1-->4-linked disaccharide analogues (2 and 3) were synthesized. Their cytotoxic activities were evaluated by the standard MTT assay. Compound 1 showed potent cytotoxicity against five types of human tumor cells, with IC50 ranging between 1.3 and 73 nM.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Zheng D,Zhou L,Guan Y,Chen X,Zhou W,Chen X,Lei P

doi

10.1016/j.bmcl.2010.07.085

subject

Has Abstract

pub_date

2010-09-15 00:00:00

pages

5439-42

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01054-1

journal_volume

20

pub_type

杂志文章

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