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Total synthesis of human chymase inhibitor methyllinderone and structure--activity relationships of its derivatives.

Abstract：

:Total synthesis of human chymase inhibitor methyllinderone has been achieved in only four steps with an overall yield of 21% from dimethyl squarate. We developed an efficient synthetic method for obtaining methyllinderone derivatives and found the active compound. In addition, we propose the inhibition mechanism of the active compound against human chymase using calculations.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Aoyama Y,Konoike T,Kanda A,Naya N,Nakajima M

doi

10.1016/s0960-894x(01)00265-7

subject

Has Abstract

pub_date

2001-07-09 00:00:00

pages

1695-7

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960894X01002657

journal_volume

11

pub_type

杂志文章

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