Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.

Abstract:

:The synthesis and biological profile of a novel series of potent and selective inhibitors of cysteine protease cathepsin K (Cat K) are described. Pharmacokinetic evaluation of 12 indicated that some members of this series could be suitable candidates to develop new orally active therapeutic agents for the treatment of osteoporosis.

journal_name

Bioorg Med Chem Lett

authors

Setti EL,Venkatraman S,Palmer JT,Xie X,Cheung H,Yu W,Wesolowski G,Robichaud J

doi

10.1016/j.bmcl.2006.05.061

subject

Has Abstract

pub_date

2006-08-15 00:00:00

pages

4296-9

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00607-X

journal_volume

16

pub_type

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