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Isolation, structure determination and cytotoxicity studies of tryptophan alkaloids from an Australian marine sponge Hyrtios sp.

Abstract：

:Mass-guided fractionation of the MeOH extract from a specimen of the Australian marine sponge Hyrtios sp. resulted in the isolation of two new tryptophan alkaloids, 6-oxofascaplysin (2), and secofascaplysic acid (3), in addition to the known metabolites fascaplysin (1) and reticulatate (4). The structures of all molecules were determined following NMR and MS data analysis. Structural ambiguities in 2 were addressed through comparison of experimental and DFT-generated theoretical NMR spectral values. Compounds 1-4 were evaluated for their cytotoxicity against a prostate cancer cell line (LNCaP) and were shown to display IC50 values ranging from 0.54 to 44.9 μM.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Khokhar S,Feng Y,Campitelli MR,Ekins MG,Hooper JN,Beattie KD,Sadowski MC,Nelson CC,Davis RA

doi

10.1016/j.bmcl.2014.05.104

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

3329-32

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00633-7

journal_volume

24

pub_type

杂志文章

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