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Synthesis and antiplatelet activity of gemfibrozil chiral analogues.

Abstract：

:The chiral analogues of gemfibrozil 5-(2,5-dimethylphenoxy)-2-methylpentanoic acid and 5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid were synthesized in optically active form using (S)-4-(1-methylethyl)-2-oxazolidinone as chiral auxiliary. All compounds inhibit human platelet aggregation. From these data, one can surmise that all tested compounds and gemfibrozil act at the platelet level with different mechanism than that of ASA, even if with a different potency.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ammazzalorso A,Amoroso R,Baraldi M,Bettoni G,Braghiroli D,De Filippis B,Duranti A,Moretti M,Tortorella P,Tricca ML,Vezzalini F

doi

10.1016/s0960-894x(02)00021-5

subject

Has Abstract

pub_date

2002-03-11 00:00:00

pages

817-21

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960894X02000215

journal_volume

12

pub_type

杂志文章

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