Abstract:
:The discovery of the potency-enhancing effect of 5-substitutions on the novel 2-arylindoles as nonpeptidyl GnRH receptor antagonists led to the identification of several analogues with high affinities on the GnRH receptor. The syntheses and SARs of these 5-substituted-2-arylindole analogues are reported.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Chu L,Lo JL,Yang YT,Cheng K,Smith RG,Fisher MH,Wyvratt MJ,Goulet MTdoi
10.1016/s0960-894x(00)00708-3subject
Has Abstractpub_date
2001-02-26 00:00:00pages
515-7issue
4eissn
0960-894Xissn
1464-3405pii
S0960894X00007083journal_volume
11pub_type
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