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Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L.

Abstract：

:Four new polyphenols namely excoecariphenols A-D (1-4) were isolated from the Chinese mangrove plant Excoecaria agallocha L. together with 23 known phenolic compounds. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses including IR, MS, NMR, and CD data. Excoecariphenols A and B presented as the unusual flavane-based 1-thioglycosides. Part of the isolated polyphenols were tested against hepatitis C NS3-4A protease and HCV RNA in huh 7.5 cells. Excoecariphenol D, corilagin, geraniin, and chebulagic acid showed potential inhibition toward HCV NS3-4A protease with IC(50) values in a range of 3.45-9.03μM, while excoecariphenol D and corilagin inhibited HCV RNA in huh 7.5 cells significantly. A primary structure-activity relationship (SAR) is discussed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Li Y,Yu S,Liu D,Proksch P,Lin W

doi

10.1016/j.bmcl.2011.11.109

subject

Has Abstract

pub_date

2012-01-15 00:00:00

pages

1099-102

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)01653-2

journal_volume

22

pub_type

杂志文章

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