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Hypocrellin derivative with improvements of red absorption and active oxygen species generation.

Abstract：

:A novel diamino-substituted hypocrellin derived from hypocrellin B (HB) was synthesized by a mild method. The red absorption of the resulting product was significantly enhanced relative to the parent hypocrellins and any other hypocrellin derivatives, and the active oxygen species generating abilities were enhanced distinctly, which will remarkably improve its photodynamic therapy effectiveness.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Xu S,Chen S,Zhang M,Shen T

doi

10.1016/j.bmcl.2004.01.003

subject

Has Abstract

pub_date

2004-03-22 00:00:00

pages

1499-501

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960894X04000289

journal_volume

14

pub_type

杂志文章

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