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Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity.

Abstract：

:Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. To investigate the structure and activity relationship of hippuristanol, we synthesized a series of analogs by expanding the size of its F ring and determined their effects on the proliferation of cancer cell lines. All changes to the F-ring of hippuristanol resulted in 3-fold to >100-fold decrease in activity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Li W,Dang Y,Liu JO,Yu B

doi

10.1016/j.bmcl.2010.03.093

subject

Has Abstract

pub_date

2010-05-15 00:00:00

pages

3112-5

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)00434-8

journal_volume

20

pub_type

杂志文章

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