Abstract:
:Three groups of non-camptothecin compounds with four to five fused rings have been designed and synthesized. Their in vitro anti-proliferative activity has been evaluated with five different cancer cell lines (HCT116, PC3, U87MG, HepG2, SK-OV-3). Compounds B-2 and B-3 showed the most potent cell growth inhibition with IC50 of 169 nM and 325 nM against U87MG cell line correspondingly.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Zhang C,Li S,Ji L,Liu S,Li Z,Li S,Meng Xdoi
10.1016/j.bmcl.2015.06.042subject
Has Abstractpub_date
2015-10-15 00:00:00pages
4693-6issue
20eissn
0960-894Xissn
1464-3405pii
S0960-894X(15)00635-6journal_volume
25pub_type
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