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Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production.

Abstract：

:A series of diphenyl ethers was prepared and evaluated for androgen receptor antagonist activity in human androgen receptor binding and cellular functional assays. Analogs with potent in vitro activities were evaluated for topical in vivo efficacy in the Golden Syrian Hamster ear model. Several compounds showed reduction in wax esters in this validated animal model.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Mitchell LH,Hu LY,Nguyen M,Fakhoury S,Smith Y,Iula D,Kostlan C,Carroll M,Dettling D,Du D,Pocalyko D,Wade K,Lefker B

doi

10.1016/j.bmcl.2009.02.104

subject

Has Abstract

pub_date

2009-04-15 00:00:00

pages

2176-8

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00273-X

journal_volume

19

pub_type

杂志文章

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