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Antibody-catalyzed cleavage of the D-Ala-D-Lac depsipeptide: an immunological approach to the problem of vancomycin resistance.

Abstract：

:Vancomycin resistance is currently a major healthcare problem. The development of a catalytic monoclonal antibody (mAb) that hydrolyzes the D-Ala-D-Lac depsipeptide provides a potentially novel antibiotic strategy. A phosphonate hapten design was used to program antibody catalysis. The characteristics of the hapten were shown to be important for obtaining a viable immune response and several catalytic mAbs that cleave a peptidoglycan model substrate. The best mAb afforded a >500-fold rate enhancement over background.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Isomura S,Ashley JA,Wirsching P,Janda KD

doi

10.1016/s0960-894x(02)00047-1

subject

Has Abstract

pub_date

2002-03-25 00:00:00

pages

861-4

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960894X02000471

journal_volume

12

pub_type

杂志文章

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