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Amplification of the inhibitory activity of miglitol by monofluorination.

Abstract：

:Selective monofluorination of the alpha-glycosidase inhibitor and antidiabetic agent Miglitol at position C2 creates an competitive inhibitor of five times higher activity than the parent compound. Its screening against a panel of human cell lines showed a low cytotoxicity therefore making this compound an interesting candidate for further clinical investigations.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Prell E,Csuk R

doi

10.1016/j.bmcl.2009.08.012

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

5673-4

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01143-3

journal_volume

19

pub_type

杂志文章

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