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Versatile synthesis of phenoxydiazirine-based fatty acid analogues and photoreactive galactosylceramide.

Abstract：

:A versatile synthesis of diazirine-based photoreactive fatty acid analogues is reported. The key step is phenoxy alkylation of diazirine with halo alkyl acid esters. The conditions described will be acceptable for the synthesis of various alkyl-length derivatives. The fatty acid derivatives are acceptors for reverse reactions of sphingolipid ceramide N-deacylase (SCDase), which catalyzes the condensation of psychosine and fatty acids to form photoreactive galactosylceramide. The photoreactive galactosylceramide can also be prepared with chemical synthesis, condensation of psychosine and fatty acid succinimidyl ester, and is recognized with anti-GarCer antibody both before and after irradiation.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Hashimoto M,Hatanaka Y,Nabeta K

doi

10.1016/s0960-894x(01)00669-2

subject

Has Abstract

pub_date

2002-01-07 00:00:00

pages

89-91

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960894X01006692

journal_volume

12

pub_type

杂志文章

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