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Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-β-carboline-4-aminoquinoline conjugates.

Abstract：

:A series of 1H-1,2,3-triazole/acylhydrazide-tethered tetrahydro-β-carboline-4-aminoquinoline conjugates was synthesized with an aim to study their anti-plasmodial structure-activity relationship. The presence of 1H-1,2,3-triazole-core along with a flexible alkyl chain length on aminoquinoline core has favourable influence on the anti-plasmodial activity against Chloroquine-resistant W2 strain of P. falciparum while the introduction of hydrazine core not only diminished the activities but also resulted in increased cytotoxicity against mammalian Vero cells.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Sharma B,Kaur S,Legac J,Rosenthal PJ,Kumar V

doi

10.1016/j.bmcl.2019.126810

subject

Has Abstract

pub_date

2020-01-15 00:00:00

pages

126810

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(19)30779-6

journal_volume

30

pub_type

杂志文章

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