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2-Arylimidazo[2,1-b]benzothiazoles: a new family of amyloid binding agents with potential for PET and SPECT imaging of Alzheimer's brain.

Abstract：

:We designed and synthesized a small series of 2-aryl-imidazo[2,1-b]benzothiazole, representing a combination of motifs from the two most potent amyloid imaging agents, PIB and IMPY. The binding affinity of the new compounds ranged from 6 to 133 nM. Among the best compounds, 3b (K(i)=6 nM) can be labeled with (11)CH(3) for PET imaging whereas 3j (K(i)=10.9 nM) can be labeled with (123)I for SPECT imaging.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Alagille D,DaCosta H,Baldwin RM,Tamagnan GD

doi

10.1016/j.bmcl.2011.03.052

subject

Has Abstract

pub_date

2011-05-15 00:00:00

pages

2966-8

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)00371-4

journal_volume

21

pub_type

杂志文章

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