Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.

Abstract:

:The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2'-anilino-4,4'-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.

journal_name

Bioorg Med Chem Lett

authors

Swahn BM,Xue Y,Arzel E,Kallin E,Magnus A,Plobeck N,Viklund J

doi

10.1016/j.bmcl.2005.11.039

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

1397-401

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)01461-7

journal_volume

16

pub_type

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