Abstract:
:The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2'-anilino-4,4'-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Swahn BM,Xue Y,Arzel E,Kallin E,Magnus A,Plobeck N,Viklund Jdoi
10.1016/j.bmcl.2005.11.039subject
Has Abstractpub_date
2006-03-01 00:00:00pages
1397-401issue
5eissn
0960-894Xissn
1464-3405pii
S0960-894X(05)01461-7journal_volume
16pub_type
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journal_title:Bioorganic & medicinal chemistry letters
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