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Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine.

Abstract：

:The design and syntheses of new fluoroquinolone antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro antibacterial activities and pharmacokinetic profiles.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Choi DR,Shin JH,Yang J,Yoon SH,Jung YH

doi

10.1016/j.bmcl.2003.12.044

subject

Has Abstract

pub_date

2004-03-08 00:00:00

pages

1273-7

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960894X03013349

journal_volume

14

pub_type

杂志文章

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