Abstract:
:The benzothiazole aniline (BTA) conjugated with monoamine-monoamide (MAMA) was synthesized and then labeled with (99m)Tc. Its corresponding rhenium analogue was synthesized, and the fluorescent staining was performed in brain sections of both Tg mouse and Alzheimer's disease (AD) patient. The fluorescent rhenium complex Re-MAMA-BTA selectively bound to the amyloid aggregates in the brain sections of both APP Tg mouse and AD patient. The analogous (99m)Tc-MAMA-BTA complex could enter the normal mouse brain with high initial uptake. These results are encouraging for further exploration of their derivatives as imaging agents for Abeta plaques in the brain.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Chen X,Yu P,Zhang L,Liu Bdoi
10.1016/j.bmcl.2007.12.071subject
Has Abstractpub_date
2008-02-15 00:00:00pages
1442-5issue
4eissn
0960-894Xissn
1464-3405pii
S0960-894X(07)01528-4journal_volume
18pub_type
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