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Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.

Abstract：

:RO4396686 is a small molecule KDR, FGFR, and PDGFR inhibitor with good pharmacokinetic properties in rodents. In a mouse corneal neovascularization assay, this compound inhibited VEGF-induced angiogenesis. Tested in a H460a xenograft tumor model this agent effected significant tumor growth inhibition at doses as low as 50mg/kg.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

McDermott LA,Higgins B,Simcox M,Luk KC,Nevins T,Kolinsky K,Smith M,Yang H,Li JK,Chen Y,Ke J,Mallalieu N,Egan T,Kolis S,Railkar A,Gerber L,Liu JJ,Konzelmann F,Zhang Z,Flynn T,Morales O,Chen Y

doi

10.1016/j.bmcl.2005.12.092

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

1950-3

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00038-2

journal_volume

16

pub_type

杂志文章

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