Abstract:
:The structural features of an anthrax lethal factor inhibitor, N-oleoyldopamine (OLDA, 1) have been probed. The oleic acid moiety is critical, but, more interestingly, the presence of the double bond and its geometry were found to play an essential role. One compound, 5, was found to be an uncompetitive inhibitor of lethal factor (LF) with a K(i) value of 2.2microM and a cell-based IC(50) value of 4.3microM.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Gaddis BD,Rubert Pérez CM,Chmielewski Jdoi
10.1016/j.bmcl.2008.02.044subject
Has Abstractpub_date
2008-04-01 00:00:00pages
2467-70issue
7eissn
0960-894Xissn
1464-3405pii
S0960-894X(08)00225-4journal_volume
18pub_type
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