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Kelsoenethiol and dikelsoenyl ether, two unique kelsoane-type sesquiterpenes, from the Formosan soft coral Nephthea erecta.

Abstract：

:Two new kelsoane-type sesquiterpenes, namely kelsoenethiol (1) and dikelsoenyl ether (2), were obtained from the Formosan soft coral Nephthea erecta. Their structures were elucidated through extensive spectroscopic analyses, ESI orbitrap mass and quantum chemical calculations (QCC). The cytotoxicity against A-459 (human lung carcinoma), P-388 (mouse lymphocytic leukemia), and HT-29 (human colon adenocarcinoma) cancer cell lines of 1 and 2 was evaluated in vitro. Compound 1 showed cytotoxicity against P-388 and HT-29 cells with ED50s of 1.3 and 1.8 μg/mL, respectively.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Cheng SY,Shih NL,Hou KY,Ger MJ,Yang CN,Wang SK,Duh CY

doi

10.1016/j.bmcl.2013.12.037

subject

Has Abstract

pub_date

2014-01-15 00:00:00

pages

473-5

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)01409-1

journal_volume

24

pub_type

杂志文章

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