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Novel BK channel openers containing dehydroabietic acid skeleton: structure-activity relationship for peripheral substituents on ring C.

Abstract：

:A series of dehydroabietic acid (DHAA, 2) derivatives was synthesized and evaluated as BK channel openers in an assay system of CHO-K1 cells expressing hBKalpha channels. Systematic modifications of the peripheral functionality of ring C of DHAA showed that the introduction of a nitro or (thio)urea group in ring C greatly enhanced the BK channel-opening activity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Cui YM,Yasutomi E,Otani Y,Yoshinaga T,Ido K,Sawada K,Ohwada T

doi

10.1016/j.bmcl.2008.08.078

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

5201-5

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01010-X

journal_volume

18

pub_type

杂志文章

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