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(R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity h5-HT1B/1D ligands.

Abstract：

:A series of (R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) have been prepared using parallel synthesis, and their structure-activity relationship studied. High affinity human 5-HT(1B/1D) (h5-HT(1B/1D)) ligands have been identified.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Egle I,MacLean N,Demchyshyn L,Edwards L,Slassi A,Tehim A

doi

10.1016/s0960-894x(03)00779-0

subject

Has Abstract

pub_date

2003-10-20 00:00:00

pages

3419-21

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960894X03007790

journal_volume

13

pub_type

杂志文章

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