Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

Abstract:

:Modulation of DNA repair pathways in oncology has been an area of intense interest in the last decade, not least as a consequence of the promising clinical activity of poly(ADP-ribose) polymerase (PARP) inhibitors. In this review article, we highlight inhibitors of the phosphatidylinositol 3-kinase related kinase (PIKK) family as of potential interest in the treatment of cancer, both in combination with DNA-damaging therapies and as stand-alone agents.

journal_name

Bioorg Med Chem Lett

authors

Finlay MR,Griffin RJ

doi

10.1016/j.bmcl.2012.06.053

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

5352-9

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00804-9

journal_volume

22

pub_type

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