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Synthesis of new conjugated coumarin-benzimidazole hybrids and their anticancer activity.

Abstract：

:A series of novel coumarin-benzimidazole hybrids, 3-(1H-benzo[d]imidazol-2-yl)-7-(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized. Six out of the newly synthesized compounds were screened for in vitro antitumor activity against preliminary 60 tumor cell lines panel assay. A significant inhibition for cancer cells was observed with compound 8 (more than 50% inhibition) compared with other compounds and active known drug 5-fluorouracil (in some cell lines) as positive control. Compound 8 displayed appreciable anticancer activities against leukemia, colon cancer and breast cancer cell lines.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Paul K,Bindal S,Luxami V

doi

10.1016/j.bmcl.2012.12.071

subject

Has Abstract

pub_date

2013-06-15 00:00:00

pages

3667-72

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)01666-6

journal_volume

23

pub_type

信件

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