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An efficient synthesis of [1,3]dioxolo[4,5-g]thieno[3,4-b]quinolin-8(5H)-ones as novel thiazapodophyllotoxin analogues with potential anticancer activity.

Abstract：

:A catalyst-free synthesis of 6,9-dihydro-[1,3]dioxolo[4,5-g]thieno[3,4-b]quinolin-8(5H)-ones as novel analogues of podophyllotoxins was developed by a three-component reaction of aldehydes, ethyl 2,4-dioxotetrahydrothiophene-3-carboxylate and 3,4-(methylenedioxy)aniline. This methodology not only provides new chemical library for the screening of anticancer activity, but also features excellent isolated yields, short reaction time, simple work up procedure and little environmental impact.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Li T,Lu T,Yu C,Yao C

doi

10.1016/j.bmcl.2015.02.047

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

1417-9

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)00167-5

journal_volume

25

pub_type

杂志文章

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