Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues.

Abstract:

:The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chain aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF2alpha.

journal_name

Bioorg Med Chem Lett

authors

deLong MA,Amburgey J,Taylor C,Wos JA,Soper DL,Wang Y,Hicks R

doi

10.1016/s0960-894x(00)00273-0

subject

Has Abstract

pub_date

2000-07-17 00:00:00

pages

1519-22

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(00)00273-0

journal_volume

10

pub_type

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