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Discovery of 3,6-diaryl-1H-pyrazolo[3,4-b]pyridines as potent anaplastic lymphoma kinase (ALK) inhibitors.

Abstract：

:A new series of 3,6-diaryl-1H-pyrazolo[3,4-b]pyridine compounds have been discovered as potent anaplastic lymphoma kinase (ALK) inhibitors. The 4-hydroxyphenyl in the 6-position of 1H-pyrazolo[3,4-b]pyridine were crucial and a fluorine atom substitution could give promising inhibitory activity. The IC50 of compound 9v against ALK was up to 1.58 nM and a binding mechanism was proposed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Chen C,Pan P,Deng Z,Wang D,Wu Q,Xu L,Hou T,Cui S

doi

10.1016/j.bmcl.2019.01.037

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

912-916

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(19)30058-7

journal_volume

29

pub_type

杂志文章

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