Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4.

Abstract:

:Two substituted biaryl analogues of colchicine and combretastatin A4, readily available through a one-step, protecting group free Suzuki-Miyaura reaction were discovered to exhibit anticancer activity while simultaneously being of low cytotoxicity to noncancerous cell lines. The compounds were shown to initiate apoptosis selectively via a mechanism involving inhibition of tubulin polymerization.

journal_name

Bioorg Med Chem Lett

authors

McNulty J,van den Berg S,Ma D,Tarade D,Joshi S,Church J

doi

10.1016/j.bmcl.2014.10.090

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

117-21

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)01161-5

journal_volume

25

pub_type

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