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Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation.

Abstract：

:Peptides containing Nepsilon-thioacetyl-lysine and Nepsilon-acetyl-lysine were evaluated for their de(thio)acetylation catalyzed by human HDAC8 and SIRT1, two distinct protein deacetylases. Nepsilon-Thioacetyl-lysine was found to be a mimic of Nepsilon-acetyl-lysine for HDAC8-catalyzed reaction, but to confer inhibition against SIRT1. These results point to further diverse applications based on Nepsilon-thioacetyl-lysine.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Fatkins DG,Monnot AD,Zheng W

doi

10.1016/j.bmcl.2006.04.075

subject

Has Abstract

pub_date

2006-07-15 00:00:00

pages

3651-6

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00506-3

journal_volume

16

pub_type

杂志文章

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