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Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents.

Abstract：

:We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 microM concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Bürli RW,Xu H,Zou X,Muller K,Golden J,Frohn M,Adlam M,Plant MH,Wong M,McElvain M,Regal K,Viswanadhan VN,Tagari P,Hungate R

doi

10.1016/j.bmcl.2006.04.068

subject

Has Abstract

pub_date

2006-07-15 00:00:00

pages

3713-8

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00493-8

journal_volume

16

pub_type

杂志文章

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