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Discovery of thienopyridines as Src-family selective Lck inhibitors.

Abstract：

:We describe the identification, SAR, and in vivo pharmacology of a new series of Src-family selective Lck inhibitors. These thienopyridines were designed based on a desire to access the unique residues in the extended hinge region of Lck.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Abbott L,Betschmann P,Burchat A,Calderwood DJ,Davis H,Hrnciar P,Hirst GC,Li B,Morytko M,Mullen K,Yang B

doi

10.1016/j.bmcl.2006.12.035

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

1167-71

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)01432-6

journal_volume

17

pub_type

杂志文章

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