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A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells.

Abstract：

:Novel arylethynyltriazole acyclonucleosides were synthesized and assessed for their anticancer activity on drug-resistant pancreatic cancer MiaPaCa-2 cells. One lead compound was found to have much more potent apoptosis-related antiproliferative effects than gemcitabine, the current first-line treatment for pancreatic cancer. Further investigations showed that this active compound did not inhibit DNA synthesis, which means that it does not resemble gemcitabine and may involve a different mechanism of action.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wang M,Xia Y,Fan Y,Rocchi P,Qu F,Iovanna JL,Peng L

doi

10.1016/j.bmcl.2010.08.093

subject

Has Abstract

pub_date

2010-10-15 00:00:00

pages

5979-83

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01229-1

journal_volume

20

pub_type

杂志文章

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