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Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor.

Abstract：

:Several efficient synthetic routes for 2-, 4-, and 6-aryl-1,2,4-triazine-3,5-diones were developed. Derivatives were synthesized and studied as gonadotropin-releasing hormone antagonists in an effort to understand structure-activity relationships of the monocyclic compounds.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Pontillo J,Guo Z,Wu D,Struthers RS,Chen C

doi

10.1016/j.bmcl.2005.06.057

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

4363-6

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00798-5

journal_volume

15

pub_type

杂志文章

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