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Targeted amplification of delivery to cell surface receptors by dendrimer self-assembly.

Abstract：

:Nanometer-scale architectures assembled on cell surface receptors from smaller macromolecular constituents generated a large amplification of fluorescence. A targeted dendrimer was synthesized from a cystamine-core G4 PAMAM dendrimer, and contained an anti-BrE3 monoclonal antibody as the targeting group, several fluorophores and an average of 12 aldehyde moieties as complementary bio-orthogonal reactive sites for the covalent assembly. A cargo dendrimer, derived from a PAMAM G4 dendrimer, contained several fluorophores as the cargo for delivery and five hydrazine moieties as complimentary bio-orthogonal reactive sites. The system is designed to be flexible and allow for facile incorporation of a variety of targeting ligands.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Isaacman S,Buckley M,Wang X,Wang EY,Liebes L,Canary JW

doi

10.1016/j.bmcl.2014.01.063

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

1290-3

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00093-6

journal_volume

24

pub_type

杂志文章

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