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Introduction of a nitroxide group on position 2 of 9-phenoxyacridine: easy access to spin labelled DNA-binding conjugates.

Abstract：

:In the search for spin labelled intercalators of general use to construct DNA-binding conjugates, 6-chloro-2-[(1-oxyl-2,2,5,5-tetramethyl- pyrrolin-3-yl)methyloxy]-9-phenoxy-acridine 5, has been prepared. This key-intermediate reacts with amines to give the corresponding labelled 9-amino substituted acridines. Comparative EPR and fluorescence measurements show that the label causes only little modification of the binding properties of acridine.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Belmont P,Chapelle C,Demeunynck M,Michon J,Michon P,Lhomme J

doi

10.1016/s0960-894x(98)00089-4

subject

Has Abstract

pub_date

1998-03-17 00:00:00

pages

669-74

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960894X98000894

journal_volume

8

pub_type

杂志文章

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