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O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.

Abstract：

:A new class of O-arylmandelic acid PPAR agonists show excellent anti-hyperglycemic efficacy in a db/db mouse model of DM2. These PPARalpha-weighted agonists do not show the typical PPARgamma associated side effects of BAT proliferation and cardiac hypertrophy in a rat tolerability assay.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Adams AD,Hu Z,von Langen D,Dadiz A,Elbrecht A,MacNaul KL,Berger JP,Zhou G,Doebber TW,Meurer R,Forrest MJ,Moller DE,Jones AB

doi

10.1016/s0960-894x(03)00702-9

subject

Has Abstract

pub_date

2003-10-06 00:00:00

pages

3185-90

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960894X03007029

journal_volume

13

pub_type

杂志文章

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