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Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase.

Abstract：

:A set of trimeric and tetrameric derivatives 6-11 of the influenza virus neuraminidase inhibitor zanamivir 1 have been synthesized by coupling a common monomeric zanamivir derivative 3 onto various multimeric carboxylic acid core groups. These discrete multimeric compounds are all significantly more antiviral than zanamivir and also show outstanding long-lasting protective activity when tested in mouse influenza infectivity experiments.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Watson KG,Cameron R,Fenton RJ,Gower D,Hamilton S,Jin B,Krippner GY,Luttick A,McConnell D,MacDonald SJ,Mason AM,Nguyen V,Tucker SP,Wu WY

doi

10.1016/j.bmcl.2003.09.102

subject

Has Abstract

pub_date

2004-03-22 00:00:00

pages

1589-92

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960894X04000757

journal_volume

14

pub_type

杂志文章

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