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Anti-HIV properties of cationic fullerene derivatives.

Abstract：

:A series of regioisomeric bis-fulleropyrrolidines bearing two ammonium groups have been synthesized and their activities against HIV-1 and HIV-2 have been evaluated. Two trans isomers have been endowed with interesting antiviral properties, confirming the importance of the relative positions of the substituent on the C(60) cage. In addition, reduced amphiphilicity of molecules to other compounds previously reported decreases their cytotoxicity in CEM cell cultures. None of the compounds showed any inhibitory activity against a variety of DNA and RNA viruses other than HIV.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Marchesan S,Da Ros T,Spalluto G,Balzarini J,Prato M

doi

10.1016/j.bmcl.2005.05.069

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

3615-8

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00624-4

journal_volume

15

pub_type

杂志文章

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