Abstract:
:The TAIRE family of kinases are an understudied branch of the CDK kinase family, that have been implicated in a number of cancers. This manuscript describes the design, synthesis and SAR of covalent CDK14 inhibitors, culminating in identification of FMF-04-159-2, a potent, covalent CDK14 inhibitor with a TAIRE kinase biased selectivity profile.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Ferguson FM,Doctor ZM,Ficarro SB,Marto JA,Kim ND,Sim T,Gray NSdoi
10.1016/j.bmcl.2019.05.024subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1985-1993issue
15eissn
0960-894Xissn
1464-3405pii
S0960-894X(19)30321-Xjournal_volume
29pub_type
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