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Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery.

Abstract：

:This communication describes the synthesis and in vitro biological evaluation of novel generation 5 PAMAM dendrimers conjugated with riboflavin as a targeting ligand. Cell-based experiments demonstrated that a dendrimer conjugated with riboflavin is able to undergo cellular binding and uptake in KB cells, and when the dendrimer is also conjugated with methotrexate, the riboflavin dendrimer conjugate can potently inhibit cell growth.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Thomas TP,Choi SK,Li MH,Kotlyar A,Baker JR Jr

doi

10.1016/j.bmcl.2010.07.005

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

5191-4

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)00949-2

journal_volume

20

pub_type

杂志文章

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