Abstract:
:A new series of triazole compounds possessing a carbon atom in place of a sulfur atom were efficiently synthesized and their in vitro antifungal activities were investigated. The carbon analogs showed excellent in vitro activity against Candida, Cryptococcus, and Aspergillus species. The MICs of compound 1c against C. albicans ATCC24433, C. neoformans TIMM1855, and A. fumigatus ATCC26430 were 0.016, 0.016, and 0.125 microg/mL, respectively (MICs of fluconazole: 0.5, >4, and >4 microg/mL; MICs of itraconazole: 0.125, 0.25, and 0.25 microg/mL).
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Uchida T,Somada A,Kagoshima Y,Konosu T,Oida Sdoi
10.1016/j.bmcl.2008.10.055subject
Has Abstractpub_date
2008-12-15 00:00:00pages
6538-41issue
24eissn
0960-894Xissn
1464-3405pii
S0960-894X(08)01240-7journal_volume
18pub_type
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