Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities.

Abstract:

:A new series of triazole compounds possessing a carbon atom in place of a sulfur atom were efficiently synthesized and their in vitro antifungal activities were investigated. The carbon analogs showed excellent in vitro activity against Candida, Cryptococcus, and Aspergillus species. The MICs of compound 1c against C. albicans ATCC24433, C. neoformans TIMM1855, and A. fumigatus ATCC26430 were 0.016, 0.016, and 0.125 microg/mL, respectively (MICs of fluconazole: 0.5, >4, and >4 microg/mL; MICs of itraconazole: 0.125, 0.25, and 0.25 microg/mL).

journal_name

Bioorg Med Chem Lett

authors

Uchida T,Somada A,Kagoshima Y,Konosu T,Oida S

doi

10.1016/j.bmcl.2008.10.055

subject

Has Abstract

pub_date

2008-12-15 00:00:00

pages

6538-41

issue

24

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01240-7

journal_volume

18

pub_type

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